Economic and historical features of the development of Moscow and the Moscow region have put their mark on the organization of the system of administrative management. The existence of Moscow and the Moscow Region as different subjects of the Russian Federation and the fulfillment by them of various roles and functions, on the one hand, and the trend towards integration and unification of Moscow and the Moscow Region within one macroregion, on the other hand, create contradictions in their interests and cause difficulties in developing a unified approach to the solution of actual economic tasks. The problems of ecology and garbage removal, hypertrophied pendulous migration and transport, forest resources’ management and water supply, which are of paramount importance both for Moscow and for the Moscow region, can be solved only on the basis of combining administrative efforts designed to develop a unified planning system for the development of this macroregion.